You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/8765
Title: 
Ascorbic acid potentiates the cytotoxicity of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • Univ Estadual Centro Oeste
ISSN: 
0031-9422
Sponsorship: 
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
  • PADC-UNESP
Abstract: 
The interaction of ascorbic acid with 5-methoxy-3,4-dehydroxanthomegnin, an 1,4-naphthoquinone, was investigated using the cytotoxic index for McCoy cells by neutral red assay. The synergstic effect was observed when such compounds were added simultaneously, most probably due to hydrogen peroxide being generated by ascorbate - driven 5-methoxy-3,4-dehydroxanthomegnin redox cycling. Incubation of cells in the presence of 5-methoxy-3,4-dehydroxanthomegnin/ascorbic acid/catalase, an enzyme that destroys H(2)O(2), resulted in an increase of cell survival, reinforcing the involvement of hydrogen peroxide generated as an important oxidizing agent that kills McCoy cells. (C) 2008 Elsevier Ltd. All rights reserved.
Issue Date: 
1-Aug-2008
Citation: 
Phytochemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 69, n. 11, p. 2205-2208, 2008.
Time Duration: 
2205-2208
Publisher: 
Pergamon-Elsevier B.V. Ltd
Keywords: 
  • Paepalanthus latipes
  • Eriocaulaceae
  • naphthoquinone
  • ascorbic acid
  • cytotoxic activity
  • antitumor drug
Source: 
http://dx.doi.org/10.1016/j.phytochem.2008.05.007
URI: 
http://hdl.handle.net/11449/8765
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/8765
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.