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http://acervodigital.unesp.br/handle/11449/8765Registro de metadados completo
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.author | Kitagawa, Rodrigo R. | - |
| dc.contributor.author | da Fonseca, Luiz M. | - |
| dc.contributor.author | Ximenes, Valdecir F. | - |
| dc.contributor.author | Khalil, Najeh M. | - |
| dc.contributor.author | Vilegas, Wagner | - |
| dc.contributor.author | Raddi, Maria Stella G. | - |
| dc.date.accessioned | 2014-05-20T13:26:57Z | - |
| dc.date.available | 2014-05-20T13:26:57Z | - |
| dc.date.issued | 2008-08-01 | - |
| dc.identifier | http://dx.doi.org/10.1016/j.phytochem.2008.05.007 | - |
| dc.identifier.citation | Phytochemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 69, n. 11, p. 2205-2208, 2008. | - |
| dc.identifier.issn | 0031-9422 | - |
| dc.identifier.uri | http://hdl.handle.net/11449/8765 | - |
| dc.description.abstract | The interaction of ascorbic acid with 5-methoxy-3,4-dehydroxanthomegnin, an 1,4-naphthoquinone, was investigated using the cytotoxic index for McCoy cells by neutral red assay. The synergstic effect was observed when such compounds were added simultaneously, most probably due to hydrogen peroxide being generated by ascorbate - driven 5-methoxy-3,4-dehydroxanthomegnin redox cycling. Incubation of cells in the presence of 5-methoxy-3,4-dehydroxanthomegnin/ascorbic acid/catalase, an enzyme that destroys H(2)O(2), resulted in an increase of cell survival, reinforcing the involvement of hydrogen peroxide generated as an important oxidizing agent that kills McCoy cells. (C) 2008 Elsevier Ltd. All rights reserved. | en |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
| dc.description.sponsorship | PADC-UNESP | - |
| dc.format.extent | 2205-2208 | - |
| dc.language.iso | eng | - |
| dc.publisher | Pergamon-Elsevier B.V. Ltd | - |
| dc.source | Web of Science | - |
| dc.subject | Paepalanthus latipes | en |
| dc.subject | Eriocaulaceae | en |
| dc.subject | naphthoquinone | en |
| dc.subject | ascorbic acid | en |
| dc.subject | cytotoxic activity | en |
| dc.subject | antitumor drug | en |
| dc.title | Ascorbic acid potentiates the cytotoxicity of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin | en |
| dc.type | outro | - |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
| dc.contributor.institution | Univ Estadual Centro Oeste | - |
| dc.description.affiliation | Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | - |
| dc.description.affiliation | Univ Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil | - |
| dc.description.affiliation | Univ Estadual Paulista, Fac Ciencias, BR-17033360 Bauru, SP, Brazil | - |
| dc.description.affiliation | Univ Estadual Centro Oeste, Dept Farm & Bioquim, BR-85040080 Guarapuava, PR, Brazil | - |
| dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | - |
| dc.description.affiliationUnesp | Univ Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil | - |
| dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Ciencias, BR-17033360 Bauru, SP, Brazil | - |
| dc.identifier.doi | 10.1016/j.phytochem.2008.05.007 | - |
| dc.identifier.wos | WOS:000258863100016 | - |
| dc.rights.accessRights | Acesso restrito | - |
| dc.relation.ispartof | Phytochemistry | - |
| dc.identifier.orcid | 0000-0003-3032-2556 | pt |
| Aparece nas coleções: | Artigos, TCCs, Teses e Dissertações da Unesp | |
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