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dc.contributor.authorKitagawa, Rodrigo R.-
dc.contributor.authorda Fonseca, Luiz M.-
dc.contributor.authorXimenes, Valdecir F.-
dc.contributor.authorKhalil, Najeh M.-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorRaddi, Maria Stella G.-
dc.date.accessioned2014-05-20T13:26:57Z-
dc.date.available2014-05-20T13:26:57Z-
dc.date.issued2008-08-01-
dc.identifierhttp://dx.doi.org/10.1016/j.phytochem.2008.05.007-
dc.identifier.citationPhytochemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 69, n. 11, p. 2205-2208, 2008.-
dc.identifier.issn0031-9422-
dc.identifier.urihttp://hdl.handle.net/11449/8765-
dc.description.abstractThe interaction of ascorbic acid with 5-methoxy-3,4-dehydroxanthomegnin, an 1,4-naphthoquinone, was investigated using the cytotoxic index for McCoy cells by neutral red assay. The synergstic effect was observed when such compounds were added simultaneously, most probably due to hydrogen peroxide being generated by ascorbate - driven 5-methoxy-3,4-dehydroxanthomegnin redox cycling. Incubation of cells in the presence of 5-methoxy-3,4-dehydroxanthomegnin/ascorbic acid/catalase, an enzyme that destroys H(2)O(2), resulted in an increase of cell survival, reinforcing the involvement of hydrogen peroxide generated as an important oxidizing agent that kills McCoy cells. (C) 2008 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipPADC-UNESP-
dc.format.extent2205-2208-
dc.language.isoeng-
dc.publisherPergamon-Elsevier B.V. Ltd-
dc.sourceWeb of Science-
dc.subjectPaepalanthus latipesen
dc.subjectEriocaulaceaeen
dc.subjectnaphthoquinoneen
dc.subjectascorbic aciden
dc.subjectcytotoxic activityen
dc.subjectantitumor drugen
dc.titleAscorbic acid potentiates the cytotoxicity of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegninen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Estadual Centro Oeste-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias, BR-17033360 Bauru, SP, Brazil-
dc.description.affiliationUniv Estadual Centro Oeste, Dept Farm & Bioquim, BR-85040080 Guarapuava, PR, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias, BR-17033360 Bauru, SP, Brazil-
dc.identifier.doi10.1016/j.phytochem.2008.05.007-
dc.identifier.wosWOS:000258863100016-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofPhytochemistry-
dc.identifier.orcid0000-0003-3032-2556pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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