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dc.contributor.authorMainardes, Rubiana Mara-
dc.contributor.authorChaud, Marco Vinicius-
dc.contributor.authorGremião, Maria Palmira Daflon-
dc.contributor.authorEvangelista, Raul Cesar-
dc.identifier.citationJournal of Nanoscience and Nanotechnology. Stevenson Ranch: Amer Scientific Publishers, v. 6, n. 9-10, p. 3057-3061, 2006.-
dc.description.abstractPraziquantel has been shown to be highly effective against all known species of Schistosoma infecting humans. Spherical nanoparticles made of poly(D,L-lactide-co-glycolide) acid with controlled size were designed as drug carriers. Praziquantel, a hydrophobic drug, was entrapped into the polymeric nanoparticles with 30% (w/w) of theoretical loading. The nanoparticles size was approximately of 350 nm with 66% of encapsulation efficiency. The everted gut sac model shows to be efficient to evaluate the drug permeation through the intestinal membrane. The results show that free praziquantel presents 4-fold times more permeation than praziquantel-loaded PLGA nanoparticles and physical mixture. For this drug, in special, this result can be interesting, since the nanoparticulate system can behave as a drug reservoir and/or to have a more localized effect in intestinal membrane for a prolonged period of time, since great amounts of parasites can be usually found in the mesenteric veins.en
dc.publisherAmer Scientific Publishers-
dc.sourceWeb of Science-
dc.subjectintestinal absorptionpt
dc.titleDevelopment of praziquantel-loaded PLGA nanoparticles and evaluation of intestinal permeation by the everted gut Sac modelen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUNESP, Programa Posgrad Ciências Farmaceut, BR-14802902 Araraquara, SP, Brazil-
dc.description.affiliationUNIMEP, Dept Ciências Saude, Piracicaba, SP, Brazil-
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Dept Farm & Medicamentos, Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Programa Posgrad Ciências Farmaceut, BR-14802902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Dept Farm & Medicamentos, Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Nanoscience and Nanotechnology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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